DARKSIDERS GENESIS shifts the series into an isometric action-RPG perspective, following Strife and War, two of the Four Horsemen, on a mission against Hell's forces. Combat combines melee and ranged attacks with cooperative play, letting a second player join the fight.

The new viewpoint changes how the series' apocalyptic mythology and dungeon-crawling puzzles are presented while keeping its core identity intact. Fans of the franchise and isometric action fans alike will find its cooperative structure a fresh angle on familiar lore.