Ghostbusters: Spirits Unleashed is an asymmetrical multiplayer game pitting a team of four Ghostbusters, armed with proton packs and traps, against a single player controlling a powerful ghost haunting the map.

Busters must scan, weaken, and capture the ghost before it drives them out, while the ghost uses stealth and mischief to sabotage their equipment, creating tense, replayable matches built around classic Ghostbusters gadgets and lore.