River City Girls 2 is the sequel to River City Girls, reuniting Misako and Kyoko for another beat-em-up adventure through River City's streets and districts. It keeps the combo-driven brawling and light RPG progression of the first game.

An expanded playable cast, more moves to unlock, shops, and side activities add depth, and friends can team up in co-op. Its colorful pixel art and soundtrack pay homage to classic arcade brawlers.