Nitroplus Blasterz Heroines Infinite Duel is a 2D fighting game bringing together heroines from various Nitroplus visual novel and anime properties for flashy, combo-heavy battles. Its fast, anime-inspired fighting system emphasizes big special moves and aerial combat.

Players pick from a roster of characters drawn from different Nitroplus franchises, competing in one-on-one matches locally or online. It's aimed at fighting-game fans and followers of Nitroplus's various series.