A Plague Tale: Requiem continues the story of Amicia and Hugo as they search for a cure to Hugo's mysterious affliction, traveling across a broader, more varied landscape while still contending with plagues of rats and the dangers that follow them.

Building on its predecessor, the game expands its blend of stealth, environmental puzzles and tense combat encounters, deepening the siblings' relationship as their journey pushes them through increasingly dangerous and emotionally weighty territory.