Vampyr is an action role-playing game set in a plague-ridden early twentieth-century London, following a doctor turned vampire struggling with his new nature. Players explore the city's districts, choosing whether to feed on citizens for power or spare them to keep the city's population intact.

Combat blends melee weapons with vampiric abilities, while conversations with civilians reveal their stories and consequences for the world around them. The game centers on moral choice, weighing personal strength against the cost paid by others.