River City Girls is a beat-em-up set in the River City universe, following two students fighting their way through the city's streets, schools, and criminal underworld to rescue their kidnapped boyfriends. Combat mixes combo-driven brawling with light RPG progression, unlocking new moves as characters level up.

Up to two players can team up locally or online, exploring interconnected city districts packed with enemies, mini-bosses, and side activities like shops and food stalls. Its retro-inspired art and soundtrack pay homage to classic arcade brawlers while adding modern polish.