Ghost of Yotei is an open-world action adventure set on the northern island of Ezo, where a lone warrior named Atsu tracks down those responsible for the destruction of her family years earlier.

Players explore snowy forests and volcanic terrain, engaging in tense sword duels and stealth encounters while uncovering the identities of a group of outlaws tied to Atsu's past, continuing the samurai-era storytelling introduced by its predecessor.