Puyo Puyo Tetris 2S is a version of Puyo Puyo Tetris 2, the puzzle game that combines Sega's chain-matching Puyo Puyo with falling-block Tetris. Players can use either style or mix them together in hybrid modes.

Head-to-head battles reward building chains and clearing lines quickly to send attacks to opponents, while a story-driven adventure mode offers solo play. Multiplayer options support both competitive and cooperative play.