Destroy All Humans is a comedic open-world action game following an alien invader armed with an arsenal of ray guns and psychic powers, sent to Earth to gather human DNA and sow chaos among 1950s small-town America. Combat mixes destructive weaponry with mind control and disguise mechanics.

Its irreverent, B-movie sci-fi humor and freedom to wreak havoc across the open world give it a distinct comedic identity. Fans of chaotic, humor-driven open-world action games will find its tone and gameplay entertaining.