Deus Ex Mankind Divided is a cyberpunk action-RPG that puts players in control of augmented agent Adam Jensen, navigating a world where mechanically enhanced humans face discrimination and unrest. Missions can be tackled through stealth, combat, or hacking, depending on how the player builds their character.

Its open-ended level design and layered conspiracy plot reward exploration and experimentation, continuing the series' focus on player choice in how objectives are approached.