Atelier Lydie & Suelle The Alchemists and the Mysterious Paintings follows twin sisters running a struggling atelier who discover paintings that serve as gateways to other worlds full of rare alchemy ingredients.

Both sisters fight side by side in the party, gathering materials from painted worlds and synthesizing them into useful items and equipment for turn based battles, as they aim to make their atelier the best in the kingdom. The dual heroine story and whimsical painted realms give this entry a lighter, more fantastical spin on the series' crafting formula.